Perfluoro-blood substitutes

It is said that one of these products, perfluoro-4-(2-cyclohexyloxyethyl) morpholine, has promising properties as a blood substitute. 

Flaim, S.F. Pharmacokinetics and side effects of perfluoro-carbon-based blood substitutes. Artif. Cells, Blood Subst., Immob. Biotech. 1994, 22, 1043-1054. 

Figure 4.23 Oxygen-car7ing capacity of human blood in comparison with pure perfluoro-n-octyl bromide (PFOB) and the blood substitute Fluosol [105] (graph modified from Ref. [102]).

Several perfluoro derivatives of 2/f-l,4-methanoquinohne (608) and 5,8-methanoquinoline (609) have found application as oxygen carriers for blood substitutes <84JAP(K)5927889,85USP4535085>. 

ECF of azabicycloalkanes in anhydrous HF forms perfluorinated derivatives, which are also potential components of blood substitutes. Thus perfluoro-A -me-thylazatricyclodecane was obtained in 8.6% yield (69ZAAC62) (Scheme 78). Perfluorinated cyclic amines are formed from 2-azatricyclo-[4.2.2.1 ]undecane... 

The high solubility of many gases, including oxygen, in fluorocarbons has led to these compounds being used as blood substitutes in cardiopulmonary machines and as potential carriers in liquid breathing. Tham et have recently measured the solubility of O2, N2, and CO2 in the three commercially available fluoro-ethers perfluoro-l,4-di-isopropoxybutane, perfluoro-1-isopropoxyhexane, and perfluorobutyl-perfluorotetrahydrofuran and noted... 

Riess, J. G. Blanc, M. L. (1978) Perfluoro Compounds as Blood Substitutes, Angew. Chem. 17, 621-640... 

Self-propelling aerosols of antiallergic, antibiotic, antitussive, or antianginal activities have been prepared using a fluorinated surfactant as the dispersant in Freon 114 and Freon 12 [203]. As an example, epinephrine bitartrate has been dispersed with perfluoro-n-octyl- -ethylsulfonamidoethyl phosphate. The use of fluorinated surfactants in intravascular oxygen carriers and blood substitutes is discussed in Chapter 10. 

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