Aerosol self-propelled

Fig. 74. Smooth endoplasmic reticulum in the apical part of a types Clara cell from a female white rat (breeder Winkel-mann, Borchen-Kirchborchen) 2 h after an inhalation of 200 mg micronized isoprenaline HCl -1- 300 /ig micronized (mass median diameter 2.45 fjm) phenylephrine bitartrate/ uff from a suspension type self-propelled aerosol (Mediha-er). 12 Puffs/min were dispersed into a 164.5 1 box where the animals stayed for 15 min. 30 min later under methitural anaesthesia, the lung was fixed by intratracheal instillation of 2.5 % glutaraldehyde in phosphate buffer (pH 7.4) before opening the thorax. Postfixation with 1 % osmium tetroxide in phosphate buffer (pH 7.4). Contrasted en bloc for 12 h with 0.5 % uranyl acetate in 70 % ethanol. Embedded in a 2 8 mixture of methyl and butyl methacrylate. Sectioned at 50 nm. Lead citrate after Reynolds (1963). Film 374/84...

Fig. 191. Plasma cells in the pulmonary interstice of a female rat (breeder Winkelmann, Borchen-Kirchborchen) which inhaled 200 ig micronized deptropine citrate/puff and 200 jg micron-ized isoprenaline hydrochloride/puff from a suspension type self-propelled aerosol (Medihaler ). 12 Puffs/min were dis-...

Self-propelling aerosols of antiallergic, antibiotic, antitussive, or antianginal activities have been prepared using a fluorinated surfactant as the dispersant in Freon 114 and Freon 12 [203]. As an example, epinephrine bitartrate has been dispersed with perfluoro-n-octyl- -ethylsulfonamidoethyl phosphate. The use of fluorinated surfactants in intravascular oxygen carriers and blood substitutes is discussed in Chapter 10. 

There is a wide range of personal care and household products packaged in the form of aerosol spray cans. These self-pressurized canisters use a propellant and a valve/atomizer to deliver a liquid aerosol. The original perfume aerosol products (circa 1903) used a CO2 propellant. The first insecticide aerosol product was developed for military use during World War II and used Freon as the propellant. The military version was called the bug bomb, and the first commercial version (1947) was called Jet [40]. Jet appears to also have been the first commercial pressurized aerosol spray product. Within a few years a number of other aerosol spray products appeared in the marketplace, including deodorants, perfumes, suntan enhancers, paints and lacquers [40]. Other modern commercial aerosol... 

Aerosol ar-o- Sal, er-, - S61 (1923) n. A suspension of liquid or solid particles in a gas (e.g., smoke, fog mist). In the packaging industry, the term means a self-contained sprayable product in which the propellant force is supplied by a compressed or liqui-dified gas (e.g., isopentane) for an aerosol spray paint. ... 

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