Percentage absorbed

The most common method of recording the absorbance of a solution was to use a micro-ammeter to measure the output of the photoelectric cell, and this method is still applied to the simplest absorptiometers. The meter is usually provided with a dual scale calibrated to read (1) percentage absorbance and (2) transmission. For quantitative measurements it is more convenient to work in terms of absorbance rather than transmittance this is emphasised by reference to the two graphs shown in Fig. 17.9. [Pg.665]

Compound Concentration (mM) Percentage absorbed Compound Concentration (mM) Percentage absorbed... [Pg.47]

The AUC associated with the mean profile for the reference, IMDUR, differs by a maximum of 17% across the studies. The reference IV profiles, constructed on an individual subject basis, were used to deconvolve the GEOMATRIX formulation data to derive the percentage absorbed for each formulation relative to the reference, from which the mean absorption profiles were calculated. The derived mean... [Pg.297]

What is noticeable is that the compounds are of low molecular weight, however, there is no simple relationship between molecular weight and percentage absorbed, probably indicating that shape and possibly flexibility are also of importance. Compounds such as propranolol (log D74, 0.9) which are related to those in Table 3.1,... [Pg.39]

Drug Percentage absorbed Partition coefficient (Kch loroloim)... [Pg.40]

Zinc load tests. Ihe appearance of zinc in the blood after a zinc load test has been used to detect differences In absorption between diets (5). Large differences in absorption can be detected with this method, but the absolute quantity of zinc absorbed or the percentage absorbed cannot be determined this way. In addition, the amount of zinc used in load tests is high compared to amounts usually consumed. Ihese factors make it difficult to extrapolate from load test results to absorption of more usual zinc Intakes. [Pg.33]

Normalize the percentage absorbed to reflect a 100 % recovery of the administered dose. This approach assumes a proportional loss of the administered dose across all analyzed moieties and is the approach typically taken with residue studies (e.g. dislodgeable residue studies). [Pg.327]

Currently, for regulatory purposes, if the area dose levels applied in the in vivo study are at or below the area dose levels anticipated to occur in the scenarios under investigation, no underestimation of dermal absorption is expected. However, if the area doses are higher than the anticipated exposure levels, the percentage absorbed, as derived from the study, should not be used as it may underestimate dermal absorption, as in general, the percentage absorption decreases with increasing dose. If the values are used, the uncertainty associated with this decision should be documented in the risk assessment. [Pg.334]

Absorption fraction The relative amount of a substance on the skin that penetrates through the epidermis into the body reported as the unitless fraction of the applied dose or as the percentage absorbed (USEPA, 1992b). [Pg.389]

Absorption percentage (percentage absorbed) The relative amount of a substance that penetrates through a barrier into the body, reported as a unitless fraction (USEPA, 1997c). [Pg.389]

Atrazine has the potential to be absorbed through the gastrointestinal tract, through the intact skin, and by inhalation. The percentage absorbed... [Pg.188]

Ethylene oxide is rapidly absorbed through the respiratory tract. Due to its high solubility in blood, uptake is largely dependent on the ventilation rate and the concentration of ethylene oxide in the inspired air. Studies in mice indicate that at 0.5 ppm, 100% of the inspired ethylene oxide is absorbed. At higher concentrations, the percentage absorbed decreases from 90% (10 ppm) to 68% (100 ppm) and falls to 36% at 1000 ppm. Humans exposed to ethylene oxide at levels ranging from 0.1 to 10 ppm absorb 75-80% of the inspired ethylene oxide. [Pg.1106]

Simulated HIA% (GastroPlus ACAT model) Figure 17.5 Correlation of experimental and simulated percentage absorbed. Percentage absorbed is defined as the percentage of the dose that crosses the apical membrane of the intestine. Percentage absorbed was simulated using the ACAT model as described in the text. [Pg.480]

Al source Al concentration Daily Al exposure iFS] Estimated percentage absorbed Daiiy Ai absorbed IfiSkg- ]... [Pg.646]

LR = percentage retained in lungs MA = percentage absorbed in mouth... [Pg.229]

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