Peptidylprolyl isomerases

PA PB diet Ph-I==0 PN FPIase pyrrolizidine alkaloid pinto bean-based diet iodosylbenzene projection neuron peptidylprolyl isomerase... 

This enzyme [EC 5.2.1.8] (also known as peptidylprolyl cis-trans isomerase, peptidylprolyl isomerase, and cyclophilin) catalyzes the interconversion of a peptidylprolyl derivative (in which co = 180°) and a peptidylprolyl derivative (in which co = 0°). 

Both tacrolimus and ciclosporin are hydrophobic and can alter the properties of the cell membrane. They bind to an intracellular peptidylprolyl isomerase that regulates... 

Thus, by 1989 it was known that the cytosolic target of each of the three immunosuppressive drugs was a peptidylprolyl isomerase. The mechanism of action of the drugs was at that time unknown, and an attractive hypothesis was that inhibition of PPIase activity was critical... 

In the 15 years since the discovery of cyclophilin there has been an enormous proliferation of known peptidylprolyl isomerases. The members of the FKBP and cyclophilin families, known collectively as the... 

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