Peptide unit layer

In order to test the speed of the D C method relative to conventional MO, single-point PM3 calculations were carried out on a series of a-helix polyalanine structures. Standard bond lengths and bond angles were used for each peptide unit, with a C-C-N-C torsional angle of —57° and an N-C-C-N torsional angle of —47°. In the D C calculations, inner and outer buffer layers of 4.0 A and 2.0 A were used, along with a matrix cutoff of 7.0 A. All computations were performed on a 32-Mbyte IBM RS/6000 Model 370 running AIX version 4.1. 

Thyroid epithelial cells synthesize and secrete T4 and T3 and make up the functional units of thyroid glandular tissue, the thyroid follicles. Thyroid follicles are hollow vesicles formed by a single layer of epithelial cells that are filled with colloid. T4,T3, and iodine are stored in the follicular colloid. T4 and T3 are derived from tyrosyl residues of the protein thyroglobulin (Tg). Thyroid follicular cells synthesize and secrete Tg into the follicular lumen. Thyroid follicular cells also remove iodide (I ) from the blood and concentrate it within the follicular lumen. Within the follicles, some of the tyrosyl residues of Tg are iodinated, and a few specific pairs of iodoty-rosyl residues may be coupled to form T4 and T3. Thus, T4, T3, and iodine (in the form of iodinated tyrosyl residues) are found within the peptide structure of the Tg that is stored in the follicular lumen. 

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