Peptide drugs synthetic

Shadidi M, Sioud M. Selective targeting of cancer cells using synthetic peptides. Drug Resist Update 2003 6 363. 

Nucleic Acids, Chemistry of Nucleic Acids, Design and Engineering of Nucleic Acid Recognition by Peptides and Drugs Synthetic Chemistry Building Molecules to Modulate Biological Systems... 

Chemists and biochemists also synthesize peptides in order to better understand how they act. By systematically altering the sequence, it s sometimes possible to find out which amino acids are intimately involved in the reactions that involve a particular peptide. Many synthetic peptides have been prepared in searching for new drugs. 

This reaction is very useful for the preparation of unnatural, nonproteinogenic amino acids that are used for the synthesis of immunostimulants, hormones, synthetic enzymes, and peptide drugs with special biological properties. 

The above-mentioned properties of polyamides in combination with their extensive use in connection with synthetic absorbable sutures in surgery demonstrate the possibility of designing iimovative polyamide-based delivery systems. Various systems are proposed to deliver protein and peptide drugs after their entrapment in nanoparticles, nanoaggregates or complexes based on polyamide backbone [449]. They are suitable for either oral or parenteral administration [450]. Polyamides have also been explored for nucleic add transportation [451,452]. Other than these pharmaceutical applications, polyamides are reported to be utilized in tissue engineering for the development of transplants to treat defedive or malfunctioning tissues and cells [453]. 

Over the last ten years, the number as well as the capacity of bulk peptide producers and peptide synthesis companies has been growing significantly throughout the world. For cancer treatment, there are 218 peptide drugs being developed in different projects." Comprehensive Medicinal Chemistry reports that around 25% of all synthetic pharmaceuticals contain at least one amide bond. In addition to pharma drugs, the amide bonds also appear as one of the most prolific moieties in agrochemicals, natural products and fine chemicals. 

Draw the full structures of the synthetic peptide drugs lanreotide and goserelin. 

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