Peptide drugs oral administration with complexes

The above-mentioned properties of polyamides in combination with their extensive use in connection with synthetic absorbable sutures in surgery demonstrate the possibility of designing iimovative polyamide-based delivery systems. Various systems are proposed to deliver protein and peptide drugs after their entrapment in nanoparticles, nanoaggregates or complexes based on polyamide backbone [449]. They are suitable for either oral or parenteral administration [450]. Polyamides have also been explored for nucleic add transportation [451,452]. Other than these pharmaceutical applications, polyamides are reported to be utilized in tissue engineering for the development of transplants to treat defedive or malfunctioning tissues and cells [453]. 

It is well known, that the co-administration of poorly water soluble drugs with a meal rich in fat can enhance the oral bioavailability of poorly water soluble drugs and lipid based delivery systems mostly based on complex lipid mixtures are intensively studied to enhance the bioavailability of poorly water soluble drugs. ° ° A couple of lipid based formulations are already on the market, e.g. for cyclosporine (Neoral ), retonavir (Norvir ), saquinavir (Fortovase ) and amprenavir (Agenerase ). Formulations of solid lipid nanoparticles may present a further alternative for oral delivery of poorly water soluble drugs as well as for proteins and peptides with low oral bioavailability due to degradation in the intestinal fluids. ... 

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