Peptide bioregulators

Bioregulators the Emerging Scientific and Technological Issues Relating to Verification and the Biological and Toxin Weapons Convention.29 This monograph was circulated to all states parties at the Review Conference. The issue of peptide bioregulators was also covered in some detail by the United States ... 

A wide variety of a-tnfluoromethyl a-amino acids are readily available from the reaction of 5-fluoro-4-tnfluoromethyl-l,3 azoles with allylic alcohols [138, 139] a-Tnfluoromethyl-subsumted a-amino acids show anubactenal and antihy pertensive activity Some are highly specific enzyme inhibitors (suicide inhibitors) and may be important as bioregulators [140] Furthermore, they are interesting candidates for peptide modification... 

Although peptides still have little market potential within the sector of pharmaceutical chemistry, one can expect their use for therapeutic purposes to increase in the future in view of their importance as bioregulators. 

A brief description of some bioregulators from a military viewpoint is given below. These peptides have been chosen based on the criteria of bioregulators intended for terrorism and warfare agents (Bokan et al, 2002). 

Bioregulators are potent low-molecular peptides and proteins that modulate a wide variety of physiological processes such as inflammation, blood clotting, and neurotransmission. Unlike most toxins, they have definite roles in the normal physiology of their hosts. Bioregulators are not normally considered poisons but at toxicological doses may produce dramatic effects on blood pressure, body temperature, and other physiological parameters. 

Classical CWAs Industrial and pharmaceutical chemicals Bioregulators and peptides Toxins Genetically modified BWAs Traditional BWAs... 

Consequently, toxins, prions, proteins, peptides and bioregulators and their biologically or synthetically produced analogues and components are covered (emphasis added). 

Phytochelatins with the general sequence (y-Glu-Cys)nGly (n = 2-11) are cysteine rich peptides synthesized by plants and are involved in metal ion bioregulation and phytoremediation. Chapters 12 and 13 of this volume are devoted to the biological... 

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