Peptic ulcer disease pathophysiology

There is now a considerable body of evidence to suggest that ROMs are involved in the pathophysiology of gastroduodenal damage. However, we await confirmation that antioxidants, such as allopurinol, are beneficial in human peptic ulcer disease. Salim (1990c) found... 

Berardi RR. Peptic ulcer disease. In DiPiro JT, et al, eds. Pharmacotherapy A Pathophysiologic Approach. 5th ed. New York McGraw-Hill 2002. 

R. M. Peek and M. J. Blaser Pathophysiology of Helicobacter pylori-induced gastritis and peptic ulcer disease. American Journal of Medicine 102,200(1997). 

The pathophysiology of peptic ulcer disease is best viewed as an imbalance between mucosal defense factors (bicarbonate, mucin, prostaglandin, nitric oxide, and other peptides and growth factors) and injurious factors (acid and pepsin). On average, patients with duodenal ulcers produce more acid... 

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