Pentoxifylline Ciprofloxacin

CIPROFLOXACIN PERIPHERAL VASODILATORS-PENTOXIFYLLINE Ciprofloxacin may t pentoxifylline levels Uncertain likely to be due to inhibition of hepatic metabolism Warn patients of the possibility of adverse effects of pentoxifylline... 

Dimensional structures of small molecules that exhibit IL-1 modulating activities. They are tenidap, ciprofloxacin, 3-Deazaadenosine, (SK F 86002), E5110, DMARDs (Chloroquine, Auranofin, Sodium aurothiomalate and Dexamethasone) tiaprofenic acid, dexamethasone, tricyclic-ylidene-acetic acid and its derivative, Probucol, eicosapentenoic acid + docosahexenoic, pentoxifylline, Denbufylline, and Romazarit (Ro-31-3948). 

The evidence suggests that ciprofloxacin inhibits the metabolism of the pentoxifylline (a xanthine derivative) by the liver. Compare Theophylline + Quinolones , p.ll92. 

Information on this interaction and its clinical relevance is limited. The author of the pharmacokinetic study suggests that, if the drugs need to be used together, the dosage of pentoxifylline should be halved. In the absence of other information, if a short-course of ciprofloxacin is required in a patient taking pentoxifylline, this may be a sensible precaution. Alternatively, because the increase in AUC was minor, it may be sufficient to recommend a reduction in pentoxifylline dose only in those who experience adverse effects (e.g. nausea, headache). Note that ciprofloxacin has been used to boost pentoxifylline levels in studies investigating the possible therapeutic value of pentoxifylline s ability to inhibit various cytokines. For example, ciprofloxacin 500 mg twice daily was used with pentoxifylline 800 mg three times daily for up to one year in patients with myelod-ysplastic syndrome. ... 

Cleary JD. Ciprofloxacin (CEPRO) and pentoxifylline (PTF) a clinically significant drug interaction. Pharmacotherapy (1992) 12, 259-60. 

Evidence from one study su ests that ciprofloxacin increases the serum levels of pentoxifylline, and may increase the incidence of adverse effects. In some clinical studies ciprofloxacin has been used to boost the levels of pentoxifylline. 

Because patients taking pentoxifylline and ciprofloxacin often complained of headache, the possibility of a pharmacokinetic interaction was studied in 6 healthy subjects. The study showed that ciprofloxacin 5(X) mg daily for 3 days increased the peak serum levels of a single 4(X)-mg dose of pentoxifylline by almost 60% (from 114.5 to 179.5 nanograms/mL), and increased the AUC by 15%. All 6 subjects complained of a frontal headache. ... 

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