Penicillium sclerotiorum

Pairet L, Wrigley SK, Chetland I, Reynolds EE, Hayes MA, Holloway J, Ainsworth AM, Katzer W, Cheng X-M, Hupe DJ, Charlton P, Doherty AM (1995) Azaphilones with Endothelin Receptor Binding Activity Produced by Penicillium sclerotiorum Taxonomy, Fermentation, Isolation, Structure Elucidation and Biological Activity. J Antibiot 48 913... 

TP Curtin, J Reilly. Sclerotiorin, C2oH2o05C1, a chlorine-containing metabolic product of Penicillium sclerotiorum van Beyma. Biochem J 34 1419-1421, 1940. 

The fungal metabolite, sclerotiorin (49) was first isolated independently by two groups from Penicillium sclerotiorum [94,95] and later from P. multicolor [95]. The 7-epimer (50) is also a known metabolite of P. hirayamae [96], Sclerotiorin was isolated for the first time from lichen mycobiont Pyrenula japonica [97]. The related rubrorotiorin (51) was also found in P. hirayamae [98]. 

Harinantenaina, L., Y. Noma, and Y. Asakawa, 2005. Penicillium sclerotiorum catalyzes the conversion of her-bertenediol into its dimers Mastigophorenes A and B. Chem. Pharm. Bull.. 53 256-257. 

The liverwort Herbertus adancus, Herbertus sakuraii, and Mastigophora diclados produce (-)-herbertene, the C3 methyl isomer of cuparene, with its hydroxy derivatives, for example, herber-tanediol (339), which shows NO production inhibitory activity (Harinantenaina et al., 2007) and herbertenol (342). Treatment of compound (339) in Penicillium sclerotiorum in Czapek-polypeptone medium gave two dimeric products, mastigophorene A (340) and mastigophorene B (341), which showed neurotrophic activity (Harinantenaina et al., 2005). 

Aspergillus niger, Penicillium italicum, Sclerotina sclerotiorum, Xanthomonas malvacearum (866). 

---