Penicillium marneffei

Xi L, Xu X, Liu W et al (2007) Differentially expressed proteins of pathogenic Penicillium marneffei in yeast and mycelial phases. J Med Microbiol 56 298-304... 

Penicillium marneffei can cause a disseminated infection in immunocompromised patients.Morphologically the organisms must be differentiated from H. capsulatum, C. neoformans, and C. albicans. The monoclonal antibody EBA-1 against the galactomannan of Aspergillus species cross-reacts with and detects P. marneffei in tissue sections. ° ° Immunohisto-chemistry has also been used to detect Blastomyces, Coccidioides, and Histoplasma. However, the antibodies have significant cross-reactivity with several other fungi. 

A similar approach has been used to prepare triazoles 11 and 12, with good antifungal activity against Aspergillus flavus, Aspergillus fumigatus, Candida albicans, Penicillium marneffei, and Trichophyton mentagrophytes, from 4-azido-8-(trifluoromethyl) quinoline 7 [7]. 

---