Penicillium marneffei infections

Penicillium marneffei can cause a disseminated infection in immunocompromised patients.Morphologically the organisms must be differentiated from H. capsulatum, C. neoformans, and C. albicans. The monoclonal antibody EBA-1 against the galactomannan of Aspergillus species cross-reacts with and detects P. marneffei in tissue sections. ° ° Immunohisto-chemistry has also been used to detect Blastomyces, Coccidioides, and Histoplasma. However, the antibodies have significant cross-reactivity with several other fungi. 

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