Penicillins allergy desensitization

Patients with a history of penicillin allergy should undergo skin testing with both peniciUoyl-polylysine and minor determinant mixtures. Patients with positive skin tests should be treated with another immunologically unrelated compound or should undergo desensitization. The management of patients with a negative skin test but a history of a severe IgE-mediated reaction has to be individualized options include the use of an alternative compound, desensitization, or the controlled administration of a test dose. 

Wendel GD Jr, Stark BJ, Jamison RB, Molina RD, Sullivan TJ. Penicillin allergy and desensitization in serious infections during pregnancy. N Engl J Med 1985 312(19) 1229-32. 

Loria RC, Finnerty N, Wedner HJ. Successful use of aztreonam in a patient who failed oral penicillin desensitization. J Allergy Clin Immunol 1989 83(4) 735-7. 

Sullivan TJ, Yecies LD, Shatz GS, Parker CW, Wedner HJ. Desensitization of patients allergic to penicillin using orally administered beta-lactam antibiotics. J Allergy Clin Immunol 1982 69(3) 275-82. 

Naclerio R, Mizrahi EA, Adkinson NF Jr. Immunologic observations during desensitization and maintenance of clinical tolerance to penicillin. J Allergy Clin Immunol 1983 71(3) 294-301. 

Gorevic PD, Levine BB (1981) Desensitization of anaphylactic hypersensitivity specific for the penicilloate minor determinant of penicillin and carbenicillin. J Allergy din Immunol 68 267... 

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