Penicillin V hydrabamine

Sheehan, J.C. U.S. Patent 3,159,617 December 1, 1964 assigned to Arthur D. Little, Inc. Doyle, F.P., Nayler, J.H.C. and Rolinson, G.N. U.S. Patent 2,941,995 June 21, 1960 assigned to Beecham Research Laboratories Limited, England 

Chemical Name N,N -Bis(dehydroabietyl)ethylendiamine bis(phenoxymethylpenicillln) Common Name — 

Approximately 1,000 g of phenoxymethylpenicillin acid (Penicillin V) is dissolved directly in about 5 liters of ethyl acetate to a concentration of 20% w/v. The resulting solution Is fil- 

In place of the hydrochlorides of the abovedescribed bases any other acid salt thereof can be used. Including both inorganic and organic salts such as phosphoric, sulfuric, and acetic acids. Also, in place of the mentioned penicillin, any of the other common salts of penicillin can be used as a source of penicillin acid. 

De Rose, A.F. U.S. Patent 2,812,326 November 5, 1957 assigned to Abbott Laboratories 

The crude dihydrochlorides of dehydroabietylethylenediamine bases (985 g) are extracted with a solution of about 3 liters of chloroform and 3 liters of water which is adjusted to about pH 10 and a second extraction is performed using a solution of about 2 liters of chloroform and the mixture readjusted to about pH 10 with 6N NaOH if necessary. The chloroform layer containing the mixed free bases is separated from the aqueous layer containing NaCI and is washed with about Vio its volume of water to remove any NaCI in the wet chloroform solution. The chloroform solution containing a mixture of the free bases having a volume of about 5 liters is dried with anhydrous NajSO and then filtered to obtain a clear solution containing about 0B5 kg of the mixed free bases. 

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Penicillin G hydrabamine Dehydroabietyl ethylene diamine Penicillin V hydrabamine 1 -Dehydro-6tt-methyl-9a-fluorohydro-cortisone Fluorometholone 6-Dehydro-17-methyltestosterone Calusterone... 

Penicillin V Hydrabamine. JV,/V -Bis(dehydro-abiefyDethylenediamine bis(phenoxymethylpenitilltn) hydrabamine phenoxymetbyl penicillin hydrabamine penicillin... 

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