Penicillins drug interactions

Drug interactions in general, there are no clinically significant drug interactions associated with the penicillins. Dicloxacillin may increase the... 

The drug interactions and adverse effects of the aminopenicillins are the same as for penicillin G. Ampicillin trihydrate may cause i.m. injection site reactions in horses mild to moderate heat, pain and/or swelling. 

Drug interactions and adverse effects of the extended-spectrum agents are the same as for penicillin G. 

Anaphyla. is is a type I reaction in which the drug ( ) interacts with IgE lixed to mast cells contrast media) can produce an anaphylaxis-like (anaphylactoid) reaction on first exposure. 

Severe drug-drug interactions are known to occur between methotrexate and NSAIDs, probenecid, and penicillin G partially due to inhibition of renal... 

OAT-mediated secretion of methotrexate. By using mouse proximal tubule cells stably expressing human transporters, methotrexate has been demonstrated to be taken up via hOAT3 and hOATl at the basolateral side of the proximal tubule and effluxed or taken up at the apical side via hOAT4, where drug interactions occur between methotrexate and NSAIDs, probenecid, and penicillin G (Takeda et al., 2002). 

An in vitro and in vivo study showed a drug interaction between penicillin and acyclovir by means of inhibition of OATl and OATS transporters, subsequently decreasing the renal excretion of acyclovir. Patients should be monitored closely for acyclovir adverse effects when given in combination with penicillin [45 ]. 

Identify the uses, general drug actions, and general adverse reactions, contraindications, precautions, and interactions of the penicillins. 

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