PDS polydioxanone

Person to discover Weipert, E A Schultz, H S Weipert, E A, US Patent 3,020,289, Wyandotte, Feb. 6,1962. Schultz, H S, US Patent 3,063,967, General Aniline Film Corp., Nov. 13, 1962. 

Details Weipert patented polymerization of dioxanone in the presence of sulfuric acid Schultz patented dioxanone polymerization in presence of organoaluminum catalyst  

Method of synthesis ring-opening polymerization of p-dioxanone in the presence of organometallic catalyst (e.g., zirconium acetylacetone) Li, Y Whng, X-L, Yang, K-K Wang, Y-Z, Polym. Bull., 57,873-880, 2006. 

Yield % 60-78 (reactive extrusion) Raquez, J-M Degee, P Dubois, P Balakrishnan, S Narayan, R, Polym. Eng. Sci., 45,622-29,2005. 

Typical impurities ppm 500 (solvents) 10 (heavy metals) 100 (catalyst)  

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Monofilament Synthetic Absorbable Sutures. Ethicon iatroduced the first monofilament synthetic absorbable suture ia 1984 when it marketed PDS polydioxanone (4) sutures. The polymer is produced by the bulk polymerisation of 2,5- -dioxanone. The suture is distributed under the trade name PDS 11. It is claimed to retain approximately 50% of its strength four weeks after implantation, 25% at six weeks, and to be absorbed within six months. 

Bartholomew, R. S., PDS (polydioxanone suture) a new S5mthetic absorbable suture in cataract surgery. A preliminary study, Ophthalmologica, 183, 81, 1981. 

Polydioxanone (PDS) is completely elirninated from the body upon absorption. The mechanism of polydioxanone degradation is similar to that observed for other synthetic bioabsorbable polymers. Polydioxanone degradation in vitro was affected by gamma irradiation dosage but not substantially by the presence of enzymes (39). The strength loss and absorption of braided PDS, but not monofilament PDS, implanted in infected wounds, however, was significantly greater than in noninfected wounds. 

Polydioxanone was the first clinically tested monofilament synthetic suture, known as PDS and marketed by Ethicon. 

Polydioxanone (PDS) was produced in the early 1980s as an absorbable suture material [33] ... 

Ray, J.A., et al, Polydioxanone (PDS), a novel monofilament synthetic absorbable suture. Surgery, Gynecology Obstetrics, 1981, 153, 497-507. 

Polydioxanone (PDS) is obtained by a ring-opening polymerization of the p-dioxanone monomer. It is characterized by a glass transition temperature in the range of -10°C to 0°C and a degree of crystallinity of about 55%. Materials prepared with PDS show enhanced flexibility due to the... 

Polydioxanone was the first polymer used commercially as monofilament for biomedical applications under the trade name PDS . As a monofilament, it has a smaller risk of infection with use and causes less friction when penetrating tissues [153], Also, the material has been used by companies like Johnson Johnson Orthopedics as an absorbable pin for fracture fixation composed of poly(dioxanone) [178],... 

Polydioxanone (PDS) HFIP 10% w/v Random smooth fibers with diameters of 2-3 pm [37]... 

Makela, P., Pohjonen, T., Tormala, P., Waris, T., Ashammakhi, N., 2002. Strength retention properties of self-reinforced poly L-lactide (SR-PLLA) sutures compared with polyglyconate (Maxon ) and polydioxanone (PDS) sutures. An in vitro study. Biomaterials 23, 2587-2592. 

N.D. Ghantarasak, and R.H. Milner, A comparison of scar quality in wounds closed under tension with PGA (Dexon) and Polydioxanone (PDS), Br. J. Plast. Surg., 42 (6), 687-691, 1989. 

J. Comah and J. Wallace, "Polydioxanone (PDS) a new material for internal suspension and fixation", British Journal of Oral and Maxillofacial Surgery, 26, 250-254, 1988. 

Polydioxanone (PDS) is a polyester of (p-dioxanone). Its key feature is essential mechanic resistance after implantation after 14 days it retains 70% of the initial resistance, but after only six months it has undergone almost complete absorption by way of hydrolysis. 

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