PDGF platelet-derived growth mechanisms

Figure 5. Crosstalk mechanisms involving sphingosine 1-phosphate (SIP) or lysophosphatidic acid (LPA). GRK2, G-protein coupled receptor kinase 2. PDGF, platelet-derived growth factor. PDGFR, platelet-derived growth factor receptor. SIP, sphingosine 1-phosphate receptor 1. MAPK, mitogen-activated protein kinase, a., alpha subunit of the heterotrimeric inhibitory G-protein, G.. py, beta/gamma subunits of a heterotrimeric G-protein.

Among the coumarins isolated from species of Artemisia (Asteraceae), esculetin (6,7-dihydroxycoumarin) and its dimethyl-ether scoparone were known to be antiproliferative on vascular smooth muscle cells. This activity was further found in some very simple mono-substituted coumarins, which were even more potent than esculetin, although less effective. In an attempt to verify its mechanism of action, esculetin was tested for interactions with PTK and PKC. The induction of membrane PTK activity by either foetal calf serum or platelet-derived growth factor (PDGF) was moderately reduced by esculetin, whereas no effect was observed against PKC [56]. 

DNA origami— hexagonal barrel with open/close mechanism Antibody Aptamers platelet-derived growth factor (PDGF) sTE17 sgc8c... 

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