Pathway Leading to Terpenoid Indole Alkaloids Intermediates and Enzymes

Here we discuss the intermediates and enzymes involved in the terpenoid indole alkaloid biosynthesis, following the subdivision into the five parts mentioned earlier (Fig. 2). In Table II the characteristics of the various 

Enzymes Characterized in Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus  

Enzyme Abbreviation Cofactors Isoforms MW (kDa) Km value Localization pH Optimum Purification cDNA Cloning Ref. 

Geraniol 10- GlOH Heme 1 56 5.5 fiM Geraniol ProvacuJoar Apparent - 108 

Tetrahydro-alstonine — NADPH 1 81 62 fjiM Iminium — — Partial - 223 

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