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Passive cutaneous anaphylaxis agents

The antiallergy activity of the pyrimido[4,5-b]quinolines was determined using the 48-hour IgE-mediated rat passive cutaneous anaphylaxis (PCA) procedure (6,2), which is widely used as a screen to identify agents with a pharmacological profile similar to intal. The compounds were administered to groups of 5 to 7 rats either intravenously in saline at pH 7.2-8.0 or orally in an aqueous solution near physiological pH (fi). Since these compounds did not demonstrate antagonism toward the anaphylactic mediators, histamine and serotonin, their activity is an indication of inhibition of mediator release. [Pg.38]

Allergic reactions of the skin are weaker after previous applications of histamine-liberating agents and also of passive cutaneous anaphylaxis (PCA). [Pg.112]

See other pages where Passive cutaneous anaphylaxis agents is mentioned: [Pg.38]    [Pg.50]    [Pg.246]    [Pg.337]    [Pg.12]    [Pg.157]    [Pg.51]    [Pg.337]    [Pg.594]    [Pg.269]    [Pg.488]    [Pg.58]    [Pg.494]    [Pg.92]   
See also in sourсe #XX -- [ Pg.51 , Pg.52 , Pg.53 , Pg.54 , Pg.55 , Pg.56 , Pg.57 , Pg.58 , Pg.59 , Pg.60 , Pg.61 , Pg.62 ]



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Anaphylaxis

CUTANEOUS

Cutan

Cutans

Passivating agents

Passive cutaneous anaphylaxis

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