PARP and Epigenetic Regulation

Several Epigenetic Modifications Work Together in the Regulation of Gene Expression 

Methylation is the only physiological postsynthetic modification of DNA able to modify DNA function and consists in the introduction of methyl groups on cytosines mainly at the CpG dinucleotides of the mammalian genome. This epigenetic modification introduces as fifth base in DNA the 5mC. It is well-known that 5mCs are distributed in a non-random fashion in genomic DNA so that the methylation pattern is characterized by the presence of methylated cytosines on the bulk of DNA while the unmethylated ones are mainly located 

Poly(ADP-Rihosyl)ation, edited by Aexander Biirkle. 2006 Landes Bioscience and Springer Science+Business Media. 

Epigenetic histone codes speak with DNA methylation about gene expression 

Inhibitioii of Poty(ADP-Ribosyl)adon Induces DNA Hypermethylation 

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