Epigenetic modifications

Example 2 Data Analysis for Epigenetic Modifications Based on ChIP-Seq... 

Sato K, Kitajima Y, Miyoshi A et al. Deficient expression of the DPD gene is caused by epigenetic modification in biliary tract cancer cells, and induces high sensitivity to 5-FU treatment. Int J Oncol... 

An experimental approach that avoids concerns about the quality of brain tissue is to study in available peripheral tissues genes or gene products that are identical to those in neural tissues. Examples include blood cells and cultured skin fibroblasts, and to a lesser extent biopsies of other tissues such as muscle (Bubber et al., 2005). Most workers assume that genes are identical in all tissues examined from an individual but worry about epigenetic modifications, to DNA as well as to post-translational and posttranscriptional products. However, extensive data indicate that study of proteins in peripheral tissues can often give critical information about those molecules in the brain the standard A striking example is the use of white blood cells and cultured skin fibroblasts to elucidate enzyme defects in inborn errors of metabolism. A well-known example is Tay-Sachs disease (GM2-gangliosidosis) (Roe and Shur, 2007). 

In the last decade, remarkable progress has been made to characterize epigenetic modifications and to associate specific patterns of modification with chromatin functionality. In this review, we will discuss the nature of DNA and histone epigenetic modifications. We will describe the modifying enzymes responsible for creating or eliminating each modification and... 

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