Parnate - Tranylcypromine sulfate

Parnate (Tranylcypromine sulfate). GlaxoSmithKline. US Prescribing information, June 2007. 

Tranylcypromine Sulfate, USP. Tranylcypromine sulfate. ( )-(ran.r-2-phcnylcyclopropylamine sulfate (Parnate), was synthesized to be an amphetamine analogue (visualize Ihc nr-mcihyl of amphetamine condensed onto Ihe fi-carbon atom). It d(x .s have. some amphetamine-like proper-lie.s. which may be why it has more immediate CNS stimulant effects than agents that act by MAO inhibition alone. For MAO inhibition, there may be two components to Ihc... 

Monoamine oxidase inhibitors (MAOI) Neurotransmitters norepinephrine, dopamine, epinephrine, and serotonin are inactive by the enzyme monoamine oxidase. MAOI inhibits monoamine oxidase, resulting in a rise in the levels of these neurotransmitters. MAOI are isocarboxazid (Marplan), phenelzine sulfate (Nardil), and tranylcypromine sulfate (Parnate). 

Monoamine oxidase inhibitor (MAOI) antidepressants have been in use for nearly 40 years. At the present time, they are viewed as second- or third-line antidepressant medications for reasons of both efficacy and safety. The available MAOIs are phenelzine sulfate (Nardil), isocarboxazid (Marplan), and tranylcypromine sulfate (Parnate). Two additional MAOI antidepressants, moclobemide and brofaromine, are approved for use in Europe and/or Canada. 

The monoamine oxidase inhibitors are used occasionally to treat depression. The hydrazine derivatives consist of isocarboxazid (Marplan) and phenelizine sulfate (Nardil). The nonhydrazine derivatives include tranylcypromine (Parnate). 

Monoamine oxidase inhibitors (MAOl) o Nialamide (Niamide) N -(2-BenzylcarbamoyT ethyl)isonicotinohydrazide o Tranylcypromine (Parnate) (+ )-fra s-2-Phe-nylcyclopropylamine sulfate (2 1) o Iproniazid (Marsilid) 2 -lsopropylisonicotino-hydrazide... 

Antidepressants are divided into the following classes the dibenzapine derivatives are called tricyclic antidepressants and include imipramine (Tofranil), desipramine (Norpramin), amitriptyline (Elavil), nortriptyline (Aventyl), protriptyline (Vivactil), and doxepin (Adapin). The monoamine oxidase inhibitors are nsed occasionally to treat depression. The hydrazine derivatives consist of isocarboxazid (Marplan) and phenelzine sulfate (Nardil). The nonhydrazine derivatives inclnde tranylcypromine (Parnate). L-Tryptophan is the only member of the monoamine precnrsors nsed to treat depression. The newer and second-generation antidepressants inclnde amoxapine, doxepin, flnoxetine, maprotiline, trazodone, mianserin, alprazolam, and bnpropion (see also Tables 5 throngh 7). 

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