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Parathyroid hormone, modified

Figure 42-13. Structure of bovine preproparathyroid hormone. Arrows indicate sites cieaved by processing enzymes in the parathyroid giand (1-5) and in the iiver after secretion of the hormone (4-5). The bioiogicaiiy active region of the moiecuie is fianked by sequence not required for activity on target receptors. (Slightly modified and reproduced, with permission, from Habener JF Recent advances in parathyroid hormone research. Clin Biochem 1981 14 223.)... Figure 42-13. Structure of bovine preproparathyroid hormone. Arrows indicate sites cieaved by processing enzymes in the parathyroid giand (1-5) and in the iiver after secretion of the hormone (4-5). The bioiogicaiiy active region of the moiecuie is fianked by sequence not required for activity on target receptors. (Slightly modified and reproduced, with permission, from Habener JF Recent advances in parathyroid hormone research. Clin Biochem 1981 14 223.)...
Parathyroid hormone (PTH) regulates calcium levels in blood and bone remodeling. The activation domain of that 84-amino acid polypeptide locates around the N-terminal (1-34 amino acids). Parathyroid hormone receptor is a typical G-protein coupled receptor, which is coupled to both adenyl cyclase/cAMP and PLCy/IP3/cytosolic Ca2+ intracellular signaling pathways. In order to identify the structural elements involved in the peptide hormone binding and signal initiation, Chorev et al. employed a photoaffinity scanning approach. The N-terminal amino acids were successively deleted or modified and the new N-terminus was replaced for photoreactive Bpa. The most active peptide ana-... [Pg.190]

P2. Pandian, M. R., Morgan, C. H., Carlton, E., and Serge, G. V., Modified immunoradiometric assay of parathyroid hormone-related protein Clinical application in the differential diagnosis of hypercalcemia. Clin. Chem. 38, 282-288 (1992). [Pg.292]

Modified from Aurbach GD, Marx SJ, Speigei AM. Parathyroid hormone, calcitonin, and the calciferols. In Wilson JD, Foster DW, eds. Williams textbook of ... [Pg.1893]

Figure 49-22 PTHrP in normal subjects and patients with malignancies and other disorders. Hatched area indicates the normal reference interval. (Adapted from Pandian AIR, Morgan CH, Carlton E, Segre GV. Modified /mmunorod/ometr/c ossoy of parathyroid hormone-related protein clinical app/icatfon in the differential diagnosis of hypercalcemia. Clin Chem 1992 38 282 SS.)... Figure 49-22 PTHrP in normal subjects and patients with malignancies and other disorders. Hatched area indicates the normal reference interval. (Adapted from Pandian AIR, Morgan CH, Carlton E, Segre GV. Modified /mmunorod/ometr/c ossoy of parathyroid hormone-related protein clinical app/icatfon in the differential diagnosis of hypercalcemia. Clin Chem 1992 38 282 SS.)...
FIG. 24 Tip current response due to superoxide anion production on stimulation of osteoclasts cultured on bone by parathyroid hormone (PTH). The Au tip diameter was 125 )jlm and was modified with cytochrome c according to the procedures of Ref. 38. The tip-specimen distance was approximately 100 /xm. (Reproduced by permission of the Society for Endocrinology from Ref. 19.)... [Pg.496]

Teriparatide modified parathyroid hormone (Forteo) 4.12 0.12 True half life (IV) 0.083 h apparent half life (SC) 1.0 SC (0.95) Osteoporosis... [Pg.349]

See other pages where Parathyroid hormone, modified is mentioned: [Pg.187]    [Pg.179]    [Pg.1261]    [Pg.189]    [Pg.2]    [Pg.127]    [Pg.95]    [Pg.95]    [Pg.95]    [Pg.62]    [Pg.214]    [Pg.270]    [Pg.1916]    [Pg.161]    [Pg.166]    [Pg.724]    [Pg.1444]    [Pg.348]    [Pg.327]    [Pg.67]   
See also in sourсe #XX -- [ Pg.349 ]



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