Paraneoplastic neurological disorders

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Rees JH, Hain SF, Johnson MR, Hughes RA, Costa DC, Ell PJ, et al. The role of [18F] fluoro-2-deoxyglucose-PET scanning in the diagnosis of paraneoplastic neurological disorders. Brain 2001 124(Pt. 11) 2223-2231. 

Darnell RB. Onconeural antigens and the paraneoplastic neurologic disorders At the intersection of cancer, immunity, and the brain. Proc Natl Acad Sci USA 1996 93(10) ... 

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Blaes F, Strittmatter M, Merkelbach S, Jost V, Klotz M, Schimrigk K, et al. Intravenous immunoglobulins in the therapy of paraneoplastic neurological disorders. J Neurol 1999 246(4) 299-303. 

Vernino S, O Neill BP, Marks RS, O Fallon JR, Kimmel DW. Immunomodulatory treatment trial for paraneoplastic neurological disorders. Neuro-oncology 2004 6(l) 55-62. 

Facioscapulohumeral muscular dystrophy (FSHD) Fragile X-associated tremor/ ataxia syndrome (FXTAS) Prader-Willi syndrome, Rett syndrome Spinocerebellar atrophy type 8 (SCA8) Paraneoplastic neurological disorders (PND)... 

Lambert-Eaton myasthenic syndrome (LEMS). Paraneoplastic neurological disorder associated with small-cell lung cancer and caused by autoantibodies against voltage-gated calcium channels. 

Cancer patients often develop symptoms from organs remote from the primary tumor. The symptoms are usually caused by metastasis or toxic effects of therapy and less often by such secondary factors as nutritional deficiency, metabolic disturbances, opportunistic infections, and effects of critical illness. Other systemic diseases such as diabetes or amyloid may become manifest or aggravated during the course of the cancer disease and cause symptoms from remote organs. Paraneoplastic neurological syndromes (PNS) are a rare cause of remote symptoms [1]. The PNS affect less than 1% of all cancer patients [2], Even in small cell lung cancer (SCLC), the tumor type most commonly associated with PNS, these disorders occur in less than 5% of the patients [3, 4],... 

Croteau D, Owainati A, Dalmau J, Rogers LR. Response to cancer therapy in a patient with a paraneoplastic choreiform disorder. Neurology 2001 57(4) 719-722. 

The paraneoplastic syndromes of the nervous system arise in association with a cancer (Darnell Posner, 2003). However, the neurological symptoms are characteristic of certain types of cancer and often precede the identification of the underlying malignancy. Therefore, proper identification of the neurological disorder will be of help in finding the cancer that causes the neurological disability. Most of these disorders are immune-mediated and characterized by the presence of autoantibodies. Sensory neuropathy and limbic... 

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