Parallel Diversomer

In 1993, DeWitt et al. described the Diversomer apparatus [57-59], which is one of the first reaction apparatus designed exclusively for the parallel synthesis of small molecules. Pipetting machines dispense reagents and solvents into vials that are located in a custom-... 

SH DeWitt, AW Czamik. Parallel organic synthesis using Parke-Davis Diversomer method. In JP Devlin, ed. High Throughput Screening The Discovery of Bioactive Substances. New York Marcel Dekker, 1997, pp. 191-208. 

Figure 2. Schematic of the Diversomer parallel synthesis apparatus.

Diversomer -technoIogy 53-56 Parallel solid-phase synthesis of individual compounds ( diversomers ) is achieved in spatially separated compartments using an apparatus allowing... 

With the concept of combinatorial chemistry and the construction of chemical libraries the issue of the structural elucidaton of active leads emerged. If compounds are generated individually in a parallel synthesis, their structure is obviously predetermined. Similarly, compounds that are physically constrained to a location are accurately defined by their position. Resourceful strategies that have been employed include the spot-synthesis on paperthe multipin, Diversomer , i27 photolitographic, and the teabag technique. ... 

A. W. Czarnik, Diversomer Technology, a practical approach to parallel simultaneous organic synthesis, conference Synthetic chemical libraries in drug discovery, London, 1995. 

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