Synthetic chemical libraries

Ohlmeyer, M. H. J., Swanson, N., Dillard, L., Header, J. C., Asouline, G., Kobayashi, R., Wigler, M., Still, W. C. (1993) Complex synthetic chemical libraries indexed with molecular tags. Proc Natl Acad Sci USA 90, 10922-10926. 

To identify an individual enriched ligand from synthetic chemical libraries (see the chapter by Zhao and Lam), the number of variants used is limited by the amount of material which is needed for sequence analysis. The use of smaller beads has been made possible by inclusion of an encryption tag, e.g. an oligonucleotide, the sequence of which can be determined after PCR [44,45], The size of such banks is, all the same, similar to phage-display libraries with some 10s molecular species per ml, using 10 pm beads [46],... 

Ohlmeyer MHJ, Swanson RN, Dillard LW, Reader JC, Asouline G, Kobayashi R, Wigler M, Still WC, Complex synthetic chemical libraries indexed with molecular tags, Proc. Natl. Acad. Sci. USA, 90 10922-10926, 1993. 

Baldwin JJ, Design, synthesis and use of binary encoded synthetic chemical libraries, Molecular Diversity, 2 81-88, 1996. 

Combinatorial chemistry refers to the synthetic chemical process that generates a set or sets (combinatorial libraries) of compounds in a simultaneous rather than a sequential manner. The broader concept of combinatorial technologies includes all of the disciplines involved in the synthesis and the applications of synthetic chemical libraries, such as their attendant analytical and computational chemistry methods and high-throughput screening (HTS, vide infra), as well as the disciplines related to other... 

M.H.J. Ohlmeyer, R.N. Swanson, L.W. Dillard, J.C. Reader, G. Asouline, R. Kobayashi, M. Wigler, W.C. StUl, Complex Synthetic Chemical Libraries Indexed with Molecular Tags , Proc. Natl. Acad. Sci. USA, 90, 10922 (1993)... 

B. MacLachlan, Presentation at the 1BC Conference on Synthetic Chemical Libraries in Drug Discovery, London 1995. 

A. W. Czarnik, Diversomer Technology, a practical approach to parallel simultaneous organic synthesis, conference Synthetic chemical libraries in drug discovery, London, 1995. 

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