Diversomer method

Workers at Parke-Davis reported the DIVERSOMER method in 1993 [63,64] which utilized proprietary reactors in combination with a Tecan robot. This technology has been implemented to generate libraries ofhydantoins [63-66,95], benzodiazepines [63-66, 95], and quinolones [67,96,97] by solid-phase synthesis. 

DeWitt SH, Czarnik AW, Combinatorial organic synthesis using Park-Davis Diversomer method, Accounts Chem. Res., 29 114-122, 1996. 

SH DeWitt, AW Czamik. Parallel organic synthesis using Parke-Davis Diversomer method. In JP Devlin, ed. High Throughput Screening The Discovery of Bioactive Substances. New York Marcel Dekker, 1997, pp. 191-208. 

Moroder, L. Lutz, J. Grams, F. Rudolph-Bohner, S. Osapay, G. Goodman, M. Kolbeck, W. A New Efficient Method for the Synthesis of 1,4-Ben-zodiazepine-2,5-dione Diversomers, Biopolymers 1996, 38, 295. 

Moroder L, Lutz J, Grams F, Rudolph-Bohner S, Osapay G, Goodman M, Kolbeck W, A new efficient method for the synthesis of 1,4-benzodiazepine-2, 5-dione diversomers, Biopolymers, 38 295-300, 1996. 

The diversomer library showed that an array of organic compounds can be synthesized, and, although the number was much smaller than that which can be achieved by most of the current methods for generating peptide and other libraries, a significant number of structural analogues was obtained in a faster way than was the case when each of the compounds was synthesized separately. 

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