Paradigm shifts for

Chapman, K., Challenges, transitions, and paradigm shifts for information technology, Pharm. Technol., 19, 120, 1995. 

Maeda, H., Greish, K. and Fang, J. The EPR Effect and Polymeric Drugs A Paradigm Shift for Cancer Chemotherapy in the 21st Century. Vol. 193, pp. 103-121. 

Pharmacogenomics represents a true paradigm shift for health care. The potential to effectively treat or cure most diseases will come at a price. These therapeutic advances will create economic and ethical dilemmas at all levels of the economy. At the individual level, there will be economic barriers to access, particularly for disadvantaged or disenfranchised populations. The costs of diagnostic tests and treatments may be prohibitive, and mechanisms (e.g., insurance, income subsidies, rationing) to distribute and pay for care must be devised. With limited health care resources, trade-offs between cost, access, and quality are inevitable. 

Wong ML, Licinio J. From monoamines to genomic targets a paradigm shift for drug discovery in depression. Nat Rev Drug Discov. 2004 3 136-151. 

Maeda H, Greish K, Fang J (2006) The EPR effect and polymeric drugs a paradigm shift for cancer chemotherapy in the 21st century. Adv Polym Sci 193 103-121... 

Fig. 10.19 A paradigm shift for equivalence classes, (a) Equivaltrace classes under enantiomtaic relationship in the conventions of stereochemistry and (b) equivalence classes under RS-stereoisomeric relationships in the present approach (Fujita 2009b)...

Takimoto CH (2008) Phase 0 clinical trials in oncology a paradigm shift for early drug development Cancer Chemother Pharmacol. 63(4) 703-9. 

A Paradigm Shift for Cancer Chemotherapy in the 21st Century... 

Chapter three Paradigm shifts for total safety... 

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