Paracoccus denitrificans, parabactin

Bergeron RJ, Dionis JB, Elliot GT, Kline SJ (1985) Mechanism and Stereospecificity of the Parabactin-mediated Iron-Transport System in Paracoccus denitrificans. J Biol Chem 260 7936... 

B) parabactin (R = H) from Paracoccus denitrificans and agrobactin (R = OH) from Agrobacterium tumefaciens ° (C) ferrichrome (D) pyochelin from Pseudomonas aeruginosa - ... 

The bacterial siderophores parabactin and compound II secreted by Paracoccus denitrificans have been shown to inhibit the growth of leukaemia cells in culture and in experimental animals. They also appear capable of inhibiting the replication of RNA viruses. 

Parabactin A, derived from hydrolysis of parabactin (the oxazoline group) exhibits a physiological reducibility. Therefore, oxazoline ring cleavage 148) may be a part of metabolic iron removal in Paracoccus denitrificans. A similar process was initially proposed and broadly accepted for the utilization of enterobactin 144). An esterase was found in the cell extracts of E. coli which cleaved the ester backbone of ferric enterobactin 14s> and desferri-enterobactin 146). In addition, it was demonstrated that... 

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