Paracetamol Beta blockers

A final example of the use of this strategy to examine futile deacetylation comes from work on the beta-blocking drug practolol where a radio-labelled 13C/14C drug was dosed to rats and the urine profiled by HPLC with UV, radioactivity, NMR and MS-MS detection [61]. As shown by the structure below, practolol can be considered to be an analogue of paracetamol with a beta-blocker side-chain ... 

Co-codamol is a combination of paracetamol (nonnapioid analgesic) and codeine (opioid analgesic). One of the side-effects of opioids is constipation. Naprosyn is a proprietary (trade name) preparation of the non-steroidal antiinflammatory drug naproxen Adalat is a proprietary preparation of the calcium-channel blocker nifedipine Amoxil is a proprietary preparation of the beta-lactam amoxicillin and Dulco-lax is the brand name of the stimulant laxative bisacodyl. 

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