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Panfuran acetyl

Amongst forty-two furan derivatives which were investigated by Dodd and Stillman in 1944 nitrofurazone was found to be highly effective as a topical agent. It contains the azomethine side chain (—CH=N—) in the 2-position of the furan ring. From 1944 to 1960 over 450 similar compounds were synthesized and studied for antimicrobial properties. Seven compounds were selected from these, namely the commercially available compounds nitrofurazone, nifuroxime, guanofuracin hydrochloride, nitrofurantoin, furazolidone and panazone. Recently acetyl- and di-(hydroxymethyl)-derivatives of panfuran have been developed for clinical use in Japan. Some physical and chemical properties of these furan derivatives are shown in Table 6.1. [Pg.322]

The azomethine group, —GH=N—, in these compounds is separated from the furan ring by an additional vinyl group, —CH=CH—. Panfuran Table 6.9) is a typical example the base is insoluble in water but soluble in acidic solution the hydrochloride is soluble to the extent of one per cent. The important compounds of the panfuran series for medicinal use are the acetyl- and di-(hydroxymethyl) derivatives, neither of which is readily soluble in water. The former is a stable compound whereas the latter is unstable. [Pg.329]

Kimura studied the sensitivity of micro-organisms to antibiotics, panfuran hydrochloride and acetyl panfuran. He used three strains of Staph, aureus, five strains of Shigella Jlexneri, and one strain of E. coli which were isolated from various clinical sources. All strains tested had remained highly sensitive to panfuran hydrochloride and acetylpanfuran but the sensitivity to antibiotics was markedly decreased. [Pg.345]


See also in sourсe #XX -- [ Pg.329 , Pg.330 , Pg.349 , Pg.368 ]

See also in sourсe #XX -- [ Pg.329 , Pg.330 , Pg.349 , Pg.368 ]




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