Pancreatic toxicity exocrine

The initial hazard identification of pancreatic toxicity in a prechnical study is always concerning because of the potentially serious human health risks, which may include fulminant, hfe-threatening cases of DIAP or a lifelong iUness, such as CP, type 1 diabetes, or pancreatic neoplasia. Because both the exocrine and the endocrine pancreas have enormous reserve capacities and there are limited sensitive and specific biomarkers to detect pancreatic injury in both animals and humans, there is always the concern that subclinical DIAP may initially go undetected in humans. Further, AP may progress until a threshold of severity is evident in minimally or asymptomatic healthy human volunteers exposed to drug candidates with unknown risks and/or in previously healthy patients that receive standard-of-care agents with marked... 

Microvascular In addition to analysis of endocrine and exocrine cell systems in the pancreas, additional cell types may play a role in the development of a drug candidate-induced pancreatic toxicity. The dense... 

Walgren, J. L., Mitchell, M. D., Whiteley, L. O., and Thompson, D. C. (2007a) Identification of novel peptide safety markers for exocrine pancreatic toxicity induced by cyanohydroxybutene. 

Al Martini s serum levels of pancreatic amylase (which digests dietary starch) and pancreatic lipase were elevated, a finding consistent with a diagnosis of acute and possibly chronic pancreatitis. The elevated levels of these enzymes in the blood are the result of their escape from the inflamed exocrine cells of the pancreas into the surrounding pancreatic veins. The cause of this inflammatory pancreatic process in this case was related to the toxic effect of acute and chronic excessive alcohol ingestion. 

Drug-Induced Pancreatic Exocrine Toxicity in Humans Pancreatitis... 

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