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Pamor antagonists

Numerous patents have appeared describing derivatives of 5 and 6 as potential PAMOR antagonists. With the exception of 5 and 6, there are no peer-reviewed publications on structure-activity relationships, in vivo activity, or other preclinical data for the new agents. As viewed from the patent literature, introduction of polar substitutents into the morphinan scaffold is the preferred peripheralization strategy. [Pg.150]


See other pages where Pamor antagonists is mentioned: [Pg.144]    [Pg.146]    [Pg.146]    [Pg.148]    [Pg.153]    [Pg.144]    [Pg.146]    [Pg.146]    [Pg.148]    [Pg.153]   
See also in sourсe #XX -- [ Pg.144 , Pg.148 , Pg.149 , Pg.150 , Pg.151 , Pg.152 ]




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