Palladium-Catalyzed Cyclization of Pyrroles

Although most of the palladium-catalyzed syntheses of indoles are discussed in later chapters, it is appropriate to present now those few examples that originate from pyrroles. 

R=CH20Me. Muratake and Natsume described the use of a Pd-catalyzed indolization en route to their synthesis of ( )-duocarmycin 3A (equation 4) [3]. 

Indole Ring Synthesis From Natural Products to Drug Discovery, First Edition. GOTdon W. Gribble. 2016 John Wiley Sons, Ltd. Published 2016 by John Wiley Sons, Ltd. 

PdCl2(Ph3P)2 Bu3SnF, LiCI xylene, reflux 

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