Pain, James

Later in the seventeenth Century Peter Pain, a French descendant of the Pain Family, moved to Bow Bridge to join the London arm of the family. During this period customers for Pains gunpowder included Charles II and James II. 

By the early nineteenth century William Pain had passed his skills on to his son James and to a nephew called Joseph Wells, but in 1837 Joseph left to establish Wells Eireworks, a company that also survived into the twentieth Century. 

In 1872 James Pain established a hreworks factory near Mitcham in Surrey before setting off to America in 1878 in the company of his son Henry to form the leading hrework company in the USA. On returning to England, James expanded the business to the extent that Pains Fireworks became renowned throughout the world. 

James Pain died in 1923 and the running of the Company became the responsibility of his other son, Philip, who died 3 years later (Figures 1.3 and 1.4). 

CONTENTS Introduction to the Series An Editor s Foreword, Albert Padwa. Preface, Bruce E. Maryanoff and Cynthia A. Maryanoff. Computer Assisted Molecular Design Related to the Protein Kinase C Receptor, Paul A. Wenderand Cynthia M. Cribbs. Chemistry and Biology of the Immunosuppressant (-)-FK-506, Ichiro Shinkai and Nolan H. Sigal. The Development of Ketorolac Impact on Pyrrole Chemistry and on Pain Therapy, Joseph M. Muchowski. Application of Silicon Chemistry in the Corticosteroid Field, Douglas A. Livingston. Hu-perzine A-A Possible Lead Structure in the Treatment of Alzheimers Disease, Alan P. Kozikowski, X.C, Tang and Israel Hanin. Mechanism-Based-Dual-Action Cephalosporins, Harry A. Albrecht and James G. Christenson. Some Thoughts on Enzyme Inhibitors and the Quiescent Affinity Label Concept, Mien Krantz Index. 

James Y. Simpson, professor of midwifery at the University of Edinburgh, introduced chloroform for the relief of labour pain. 

Bloch MB, Dyer RA, Heijke SA, James MF. Tramadol infusion for postthoracotomy pain relief a placebo-con-trolled comparison with epidural morphine. Anesth Analg 2002 94(3) 523-8. 

Fox A, Kesingland A, Gentry C, McNair K, Patel S, Urban L, James I (2001) The role of central and peripheral cannabinoid 1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. Pain 92 91-100... 

James Young Simpson was dissatisfied with the time required for ether-induced anesthesia and received from a chemist friend of his, three chloroform-based liquids. He then tested these products on his friends and family for anesthetic potential Of the samples tested, chloroform provided the most rapid and effective anesthesia. Simpson went on to use chloroform with great success in controlling pain of childbirth but this did not come without controversy. The church fought the use of anesthetics in something so divine as childbirth. Even at this time fundamentalism was still supreme but Simpson ultimately won the day by arguing that the Bible states clearly how Adam was put to sleep before Eve was bom from him. 

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