P-Aminobenzaldehyde

Virus replication comprises numerous biochemieal transformations that might provide suitable targets for antiviral therapy. The antiviral effect of thiosemicarbazones was first demonstrated by Hamre et al. [53, 54], who showed that p-aminobenzaldehyde-3-thiosemicarbazone and several of its derivatives were active against vaccinia virus in mice. These studies were extended to include thiosemicarbazones of isatin, benzene, thiophene, pyridine, and quinoline derivatives, which also showed activity against vaccinia-induced encephalitis. The nature of the aldehyde/ketone moiety was not as significant as the presence of the thiosemicarbazide side chain the latter was deemed essential for antiviral activity. 

Similar reducing effects are obtained from alkali sulfides, hydrosulfides and polysulfides [241]. A peculiar reaction believed to be due to sodium polysulfide formed in situ by refluxing sulfur in aqueous-ethanolic sodium hydroxide is a conversion of p-nitrotoluene to p-aminobenzaldehyde [242]. Oxidation of the methyl group by the polysulfide generates hydrogen sulfide which then reduces the nitro group to the amino group. 

Test for indole Indole is a component of the amino acid tryptophan, which can he broken down by the bacterial enzyme tryptophanase. When tryptophan is broken down, the presence of indole can be detected through the use of Kovacs reagent. Kovacs reagent, which is yellow, reacts with indole and produces a red colour on the surface of the test tube. Kovacs reagent is prepared by dissolving 10 g of p-aminobenzaldehyde in 150 mL of isoamylalcohol and then slowly adding 50 mL of concentrated HCl. 

A peculiar oxido-reductive reaction takes place when p-aminotoluene is heated with sodium polysulfide the product is p-aminobenzaldehyde [505]. 

Oxystarch reacted with phenylhydrazine to give a yellow compound" " which contained one basic group per dialdehyde unit." Similar reactions were found with isonicotinoylhydrazine, thiosemicarbazide, and p-aminobenzaldehyde thiosemicarbazone. Structures of the general type (97) were assigned to these polymers." That this structure is incorrect for the phenylhydrazine derivative was shown by its formation of a poly(di-phenylformazan). Mester therefore suggested structure (104) for the... 

The preparation of fuchsine illustrates the formation of a typical triphenylmethane dye but does not show the relations of the colored substance to the compounds which are formed in the intermediate steps. These may be represented by equations. When p-toluidine is oxidized it forms p-aminobenzaldehyde, which condenses with aniline to form triaminotriphenyhnethane. 

Disproportionation. p-Nitrotoluene, heated with a solution of 0.125 mole of sodium sulfite nonahydrate (freshly opened), 0.47 gram atom of flowers of sulfur, and 0.67 mole of sodium hydroxide pellets in 600 ml. distilled water, undergoes disproportionation to give golden yellow needles of p-aminobenzaldehyde.12... 

Aluminum amalgam, 7, 275 Aluminum bromide, 7 Aluminum chloride, 6, 7-9, 49, 295, 299 Aluminum hydride, 9-10, 46 Aluminum isopropoxide, 10 Amalgamated aluminum, 7 Amalgamated magnesium, 7 Amidation, 17 Amides, 23, 147, 277 1-Aminoadamantanes, 295 (3-Amino alcohols, 162 p-Aminobenzaldehyde, 272 2,2 -Aminobenzophenones, 166... 

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