P-Adrenergic blocking drugs

Esmolol hydrochloride is a competitive p-adrenergic receptor antagonist it is selective for pT adrenoceptors. In contrast to pindolol, esmolol has little intrinsic sympathomimetic activity, and it differs from propranolol in that it lacks membrane stabilizing activity Of all of the p-adrenergic blocking drugs, this compound has the shortest duration of action because it is an ester, it is hydrolyzed rapidly by plasma esterases and must be used by the intravenous route Esmolol is approved only for the treatment of supraventricular arrhythmias... 

A fine resting tremor is a common side effect. P-Adrenergic-blocking drugs, such as propranolol (<80 mg/day in divided doses), are effective in treating this tremor. Subjective memory impairment commonly occurs and is among the most frequent reasons for noncomphance (Goodwin and Jamison 1990). 

Hamoir, T. Massart, D.L. Retention prediction for p-adrenergic blocking drugs in normal-phase liquid chromatography. J.ChromatogrA, 1994, 673, 1-10 [column temp 30 cyanopropyl column also ace-butolol, alprenolol, bunitrolol, bupranolol, carazolol, mepindolol, metipranolol, metoprolol, nadolol, oxprenolol, penbutolol, pindolol, practolol, prenalterol, propranolol, tertatolol]... 

Hamoir, T. Verlinden, Y Massart, D.L. Reversed-phase liquid chromatography of p-adrenergic blocking drugs in the presence of a tailing suppressor. J.Chromatogr.Sci., 1994, 32, 14-20... 

When administering a p-adrenergic blocking drug, such as propranolol (inderal), the nurse should take an apical pulse rate and blood pressure before giving the drug. If pulse is below 60 bpm or if sy olic blood pressure is less than 90 mm Hg, the nurse should withhold the drug and contad the primary health care provider. 

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