Oxytocin pharmacologic properties

D. Jarvis, M. Bodanszky, V. du Vigneaud, The synthesis of l-(hemihomocystine)-oxytocin and a study of some of its pharmacological properties. J. Amer. Chem. Soc. 83 4780-4784 (1961)... 

V. du Vigneaud, P.S. Fitt, M. Bodanszky, M. O Connell, Synthesis and some pharmacological properties of a peptide derivative of oxytocin glycyl-oxytocin. Soc. Exptl. Biol. Med. 104 653-656 (1960)... 

The subject 0xytocin - molecular aspects can be treated from various points of view. One of the possible approaches is the following To-day we have quantitative data on a nximber of well-defined pharmacological properties for more than 200 synthetic peptides of the nexirohypophysial type, which can all be considered to be derivatives of oxytocin. Therefore, it is tempting to try to discover, on the basis of the pharmacological properties of these derivatives, which parts of the oxytocin molecule are essential for the characteristic biological effects of this hormone. 

COMPARISON OF THE PHARMACOLOGICAL PROPERTIES OF TWO HIGHLY POTENT, CRYSTALLINE NEUROHYPOPHYSEAL HORMONE ANALOGS DEAMINO-1-SELENO-OXYTOCIN AND DEAMINO-OXYTOCIN... 

Uterine contractions and fetal heart rate should be monitored during oxytocin administration (SEDA-13, 1310) (1,2). There is no significant increase in uterine complications or in fetal morbidity or mortality in women with a previous cesarean section, although oxytocin-treated patients had a higher rate of failed trial of labor for reasons that are unclear (3). Oxytocin is structurally similar to vasopressin, and like the latter has water-retaining properties when used in pharmacological doses. 

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