Oxygenase inducible

Garcia-Perris, C., and Moreno, J. (1994). Oxidative modification and brealidown of ribulose-1,5-bisphosphate carboxylase oxygenase induced in Euglena gracilis by nitrogen starvation. Planta. 193, 208-215. 

All mammalian cells are virtually capable of producing CO with heme as the main substrate (Fig. 1) [5]. Enzymatic heme metabolism in vivo is mainly catalyzed by heme oxygenase (HO). In the presence of HO, the porphyrin ring of heme is broken and oxidized at the a-methene bridge, producing equimolar amounts of CO, ferrous iron, and biliverdin. Three isoforms of HO have been identified. Inducible HO-1 (32 kDa) is mostly recognized for its upregulation in response... 

Laboratory trials during lampricide application (0.5-5.8 mg/L, 24-h exposure) with rainbow trout confirmed that field formulations of lampricides induce hepatic mixed function oxygenase enzymes activity. Mixed function oxygenase induction was associated with the 3-trifluoromethyl-4-nitrophenol formulation, and not the 2, 5-dichloroU -nitrosalicylanilidc (Bayer 73) component of the field application. Bioassays were successfully confirmed with HPLC [78]. 

Parsadaniantz, S. M. et al. Effects of the inhibition of cyclo-oxygenase 1 or 2 or 5-lipoxy-genase on the activation of the hypothalamic-pituitary-adrenal axis induced by interleukin-lbeta in the male Rat. J. Neuroendocrinol. 12, 766, 2000. 

Both mirex and chlordecone are microsomal enzyme inducers, and as such enhance the metabolism of compounds oxidized or reduced by the mixed function oxygenase system. For... 

TCE is the other major contaminant at the site and is a common groundwater contaminant in aquifers throughout the United States [425]. Since TCE is a suspected carcinogen, the fate and transport of TCE in the environment and its microbial degradation have been extensively studied [25,63, 95,268,426,427]. Reductive dechlorination under anaerobic conditions and aerobic co-metabolic processes are the predominant pathways for TCE transformation. In aerobic co-metabolic processes, oxidation of TCE is catalyzed by the enzymes induced and expressed for the initial oxidation of the growth substrates [25, 63, 268, 426]. Several growth substrates such as methane, propane, butane, phenol, and toluene have been shown to induce oxygenase enzymes which co-metabolize TCE [428]. 

Parrott, J.L. and Tillitt, D.E. 1997,The use of Semipermeable Membrane Devices (SPMDs) to Concentrate Inducers of Fish Hepatic Mixed Function Oxygenase (MFO). In Ecotoxicology Responses, Biomarkers, and Risk Assessment. An OECD Workshop Zelikoff, J.T., Ed. SOS Publications Pair Haven, NJ. pp. 185—196. 

O. N. Tucker, A. J. Dannenberg, E. K. Yang and T. J. Fahey III, Bile acids induce cyclo-oxygenase-2 expression in human pancreatic cancer cell lines. Carcinogenesis, 2004, 25(3), 419. 

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