Oxygen poisoning

There are numerous indications in the literature on catalyst deactivation attributed to over-oxidation of the catalyst (3-5). In the oxidative dehydrogenation of alcohols the surface M° sites are active and the rate of oxygen supply from the gas phase to the catalyst surface should be adjusted to that of the surface chemical reaction to avoid "oxygen poisoning". The other important reason for deactivation is the by-products formation and their strong adsorption on active sites. This type of... 

We believe that the primary reason of deactivation is the formation of irreversibly adsorbed species and oxygen poisoning occurs when the blocking of active sites reaches a critical level. By-products can be formed during the oxidation reaction. A frequently observed side-reaction is the aldol-dimerization of the carbonyl compound and a further oxidation of the product. The process is catalyzed by bases, including the basic functional groups of a carbon support (25). 

Geischman, R., etal. Oxygen Poisoning and X-irradiation A Mechanism in Common, Science, 119, 623 (1954). 

Because of their extreme reactivity, the existence of free radicals in biological systems was generally not considered possible until Gerschman and associates (G3) hypothesized that oxygen poisoning and X-irradiation have a common basis of action. Here, they reported the homolytic dissociation of water by ionizing radiation. 

Gardner, P.R., Nguyen, D.D., White, C.W. (1994). Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs. Proc. Natl Acad. Sci. USA 91 12248-52. 

Gerschman R, Gilbert DL, Nye SW, Dwyer P, Fenn WO. Oxygen poisoning and X-radiation a mechanism in common. Science 119 (1954) 623-626. 

In cases of pulmonary irritation, the oxygen concentration should be reduced to 60% or less. With oxygen poisoning, the oxygen concentration should be reduced to 200 mm kg... 

Survival time increased, ultimate mortality unaffected. Signs of oxygen poisoning on death 287... 

The activity of nickel was completely destroyed by an irradiation to about 2 X 1013 ot/cm2, which required a little more than an hour. A 5-hour evacuation at room temperature reduced the activity only about as much as an irradiation to 2-4 x lOi a/cm (60). The evacuation afforded a better opportunity for oxygen poisoning for a longer time but had far less effect than the irradiation to 2 x 10i3 a/cm. ... 

B5. Barker, J., and Mapson, L. W., Studies in the respiratory and carbohydrate metabolism of plant tissues. VII. Experimental studies with potato tubers of an inhibition of the respiration and of a block in the tricarboxylic acid cycle induced by oxygen poisoning. Proc. Roy. Soc. B143, 523-549 (1955). 

C3. Campbell, J. A., Oxygen poisoning and tumor growth. Brit. J. Exptl. Pathol. 18, 191-197 (1937). 

C20. Collier, C. R., Alterations of surfactant in oxygen poisoning. Proc. 30th Ann. Meeting, Am. CoU. Chest Physicians p. 50 (1964). 

H6. Haugaard, N., Oxygen poisoning. The relation between inactivation of enzymes by oxygen and essential sulfhydryl groups. J. Biol. Chem. 164, 265-270 (1946). 

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