Oxygen Oxygenase

With an iron-sulphur protein as acceptor Acting on single donors with incorporation of molecular oxygen (oxygenases) 1.18 1.18.1 Acting on reduced ferredoxin as donor With NAD+ or NADP+ as acceptor... 

Acting on single donors with incorporation of oxygen (oxygenases)... 

Oxidoreductases Acting on Single Donors with incorporation of Molecular Oxygen (Oxygenases)... 

Oxygenases - add one (monooxygenases) or both (dioxygenases) atoms of molecular oxygen to molecules, eg... 

Samuel, D. (1962). Methodology of oxygen isotopes. In Hayaishi, O. (ed.), Oxygenases, pp. 31-86. Academic Press, New York. 

P450 Mono-oxygenase System Reactive Oxygene Species Oxidative Stress Vitamin C Vitamin E... 

Cytochrome P450 (CYP) mono-oxygenases, also called mixed function oxidases, are versatile hemoprotein enzymes that catalyze the cleavage of molecular oxygen to incoiporate one oxygen atom into a substrate molecule and one atom into water [1]. The general stoichiometry of the reaction is as follows (S-H, substrate) ... 

OXYGENASES CATALYZE THE DIRECT TRANSFER INCORPORATION OF OXYGEN INTO A SUBSTRATE MOLECULE... 

Oxygenases are concerned with the synthesis or degradation of many different types of metabolites. They catalyze the incorporation of oxygen into a substrate molecule in two steps (1) oxygen is bound to the enzyme at the active site, and (2) the bound oxygen is reduced or transferred to the substrate. Oxygenases may be divided into two subgroups, as follows. 

Carotene cleavage enzymes — Two pathways have been described for P-carotene conversion to vitamin A (central and eccentric cleavage pathways) and reviewed recently. The major pathway is the central cleavage catalyzed by a cytosolic enzyme, p-carotene 15,15-oxygenase (BCO EC 1.13.1.21 or EC 1.14.99.36), which cleaves p-carotene at its central double bond (15,15 ) to form retinal. Two enzymatic mechanisms have been proposed (1) a dioxygenase reaction (EC 1.13.11.21) that requires O2 and yields a dioxetane as an intermediate and (2) a monooxygenase reaction (EC 1.14.99.36) that requires two oxygen atoms from two different sources (O2 and H2O) and yields an epoxide as an intermediate. ... 

Branchaud BP, CT Walsh (1985) Functional group diversity in enzymatic oxygenation reactions catalyzed by bacterial flavin-containing cyclohexanone oxygenase. J Amer Chem Soc 107 2153-2161. 

Matsui T, M Furukawa, M Unno, T Tomita, M Ikeda-Saito (2005) Roles of distal Asp in heme oxygenase from Corynebacterium diphtheriae, HmuO. A water-driven oxygen activation system. J Biol Chem 280 2981-2989. 

Colby J, DI Stirling, H Dalton (1977) The soluble methane mono-oxygenase of Methylococcus capsulatus (Bath). Its ability to oxygenate -alkanes, -alkenes, ethers, and alicyclic, aromatic and heterocyclic compounds. Biochem J 165 395-401. 

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