Oxygen hypoxia inducible factor

Diabetes is hypothesized to cause cardiac protein acetylation and the acetylation alters the protein function (Fig. 3b). Hypoxia-inducible factor-1 (HIFl) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. Diabetes interferes with cellular response to hypoxia. In hyperglycemic conditions HIFl degradation is increased because of enhanced HIFl acetylation by... 

Responses to low oxygen tension in tissues (hypoxia) are important to all aerobic organisms.464/467a d In mammals transcription of hypoxia-responsive genes is regulated by hypoxia inducible factors HIF-1 and... 

Semenza GL (2001) Hypoxia-inducible factor 1 oxygen homeostasis and disease pathophysiology. Trends Mol Med 7(8) 345-350... 

Wang, G.L., B-H. Jiang, E.A. Rue, and G.L. Semenza (1995). Hypoxia inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular oxygen tension. Proc. Natl. Acad. Sci. USA 92 5510-5514. 

Srinivas V, Zhang L-P, Zhu X-H, Caro J. Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor a (HIF-a) proteins. Biochem. Biophys. Res. Commun. 1999 260 557-561. 

Ehrismann D, Flashman E, Genn DN, Mathioudakis N, Hewitson KS, Ratcliffe PJ, Schofield CJ. Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. Biochem. J. 2007 401 227-234. 

Appelhoff RJ, Tian YM, Raval RR, Turley H, Hands AL, Pugh CW, Ratcliffe PJ, Gleadle JM. Differential function of the prolyl hydroxylases, PHDl, 2 and 3 in the regulation of hypoxia inducible factor (HIF). J. Biol. Chem. 2004 279 38458-38465. Berra E, Benizri E, Ginouves A, Vofinat V, Roux D, Pouysse-gur J. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-la in normoxia. EMBO J. 2003 22 4082-4090. 

Cash TP, Pan Y, Simon MC. Reactive oxygen species and cellular oxygen sensing. Free Radic. Biol. Med. 2007 43 1219-1225. Gorlach A, Kietzmann T. Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors. Methods Enzymol. 2007 435 421-446. 

Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, Schumacker PT. Reactive oxygen species generated at mitochondrial complex m stabilize hypoxia-inducible factor-lalpha during hypoxia a mechanism of O2 sensing. J. Biol. Chem. 2000 275 25130-25138. 

McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Lienard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, Syed RS, Schofield CJ. Cellular oxygen sensing crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). Proc. Natl. Acad. Sci. U.S.A. 2006 103 9814-9819. 

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999 399 141. 

HIE Hypoxia inducible factor, a transcription factor that responds to changes in available oxygen in the cellular... 

Ubiquitylation is required for the degradation of hypoxia inducible factor (HIF) on hydroxylation at high oxygen levels (120). Maintaining the circadian clock requires the ubiquitylation and degradation of proteins that inhibit the CLOCK (a protein named from circadian locomotor output cycles kaput gene) transcription factor (121). 

Hypoxia inducible factor 1 alpha (HIF-la) is a transcription factor that responds directly to intracellular levels of oxygen. When levels become reduced due to mismatch of cellular oxygen supply and... 

Ratcliffe, P.J., J.E. O Rourke, P.H. Maxwell and C.W. Pugh. Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression. J. Exp. Biol. 201 1153-1162, 1998. 

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