Oxygen clinical applications

Long-Term Oxygen Therapy Scientific Basis and Clinical Application, edited by W. J. O Donohue, Jr. 

Triplet states of xanthone depend upon the composition of the solvent the presence of water enhances the yield of 2 un state Dual phosphorescence from 2-(2 -hydroxyphenyl) benzoxazole is due to keto-enol tautomerism and the kinetics multi-exponential decay is due to differences of environment . Triplet state properties and triplet state-oxygen interactions of the biologically interesting linear and angular furocoumarins are useful in view of possible clinical application . 

Hirth et al. studied the clinical application of NIR in migraine patients [47]. They assessed the transient changes of brain tissue oxygenation during the aura and headache phases of a migraine attack. 

Y. Nagashima, Y. Yada, M. Hattori, and A. Sakai, Development of a New Instrument to Measure Oxygen Saturation and Total Hemoglobin Volume in Local Skin by Near-Infrared Spectroscopy and Its Clinical Application, Int. J. Biometrology, 44(1), 9-11 (2000). 

Similar optical biosensors have been prepared for many other analytes. For example, a cholesterol optical biosensor has been devised based on fluorescence quenching of an oxygen-sensitive dye that is coupled to consumption of oxygen resulting from the enzyme-catalyzed oxidation of cholesterol by the enzyme cholesterol oxidase. Serum bilirubin has been detected using bilirubin oxidase, coimmobilized with a ruthenium dye, on an optical fiber.The bilirubin sensor was reported to exhibit a lower detection limit of iO Xmol/L, a linear range up to 30mmol/L, and a typical reproducibihty of 3% (CV), certainly adequate for clinical application. 

In a similar manner, enzyme-containing membranes have been coupled with electrochemical devices such as an oxygen electrode to form enzyme sensors for a variety of biochemical and clinical applications (Table II). Considerable effort has been concentrated on the development of these enzyme sensors (83-86). 

B4. Barclay, R. S., Ledingham, I. McA., and Norman, J. N., Experimental and human cardiac surgery with hyperbaric oxygen. In Clinical Application of Hyperbaric Oxygen (I. Boerema, W. H. Brummelkamp, and N. G. Meijne, eds.), pp. 197-201. Elsevier, Amsterdam, 1964. 

---