Oxyacetic acids

Ci2HigN2Og H20 Uridine-5-oxyacetic acid, methyl ester, monohydrate UROAME 34 369... 

Isolated primary rat hepatocytes in the respirometer chamber at 106 cells ml 1 exhibited robust H2S production, achieving concentrations of >20 pM in 30min as the 02 concentration decreased and in the presence of L-cysteine and PLP (Kraus et al., preliminary data, not shown). Inhibitors of both CBS and CGL (amino oxyacetic acid and propargylglycine, respectively) inhibited H2S production, indicating the presence of both enzymes in hepatocytes. 

The chemical strucmre of a substance may contain strucmral alerts for reproductive toxicity, based on clear evidence for reproductive toxicity of strucmral analogues. For example, glycol ethers, which are metabolized to a reproductive toxic metabolite (an oxyacetic acid) should be considered as reproductive toxicants unless data are available showing no reproductive toxicity of the substance under evaluation. 

The substituents at the 5 or 6 position of the pyrimidine base have no relation to the susceptibility to RNase T2. Madison and Holley 93) have shown that RNase T2 is able to split the phosphodiester bonds of pseudouridylic acid and 5,6-dihydrouridylic acid. Recently, Saneyoshi et al. 86) have found a new minor constituent, Vp, with 5-methyl cytidine 3 -phosphate and other mononucleotides on the two-dimensional paper chromatogram of RNase T2 exhaustive digest of E. coli tRNAVal later the structure of V was proved to be uridine-5-oxyacetic acid 94). 

In related work,20 these same authors evaluated a fluorinated crown ether carboxylic acid,. rym-difluorobenzo-16-cniwn-5 oxyacetic acid, for use in the SCF extraction of uranyl ion and lanthanides, again from a cellulose matrix. Although this compound... 

Wang, X. Li, Z. Da, Y. Chen, J. Wei, T. Phase transfer catalyzed synthesis of 4-carboxylphen-oxyacetic acid derivatives. Synth. Commun. 1999, 29, 4153-4161. 

Dicyanomethylidene)-2,6-di-/ert.-butyl (or phenyl)-4//-tellurin was oxidized by per-oxyacetic acid and converted to the 7e,7e-diacetate by acetic acid in dichloromethane1. 

CDNSA is dinonylnaphthalene sulfonic acid. dDB16C5AA is dibenzo-16-crown-5-oxyacetic acid. 

Agent Orange 2,4-dichlorophenoxyacetic acid (2, 4-D) and 2,4,5-trichlorophen-oxyacetic acid (2,4,5-T) dioxin... 

Iroexll and Benzadox. A wood-degrading basldlomycete, Iroex Dachvodon. produces Irpexll [47], which had antibacterial activity (1891. Later, the compound was found to have phytotoxic properties and to be structurally related to several synthetic herbicides. Including benzadox (benzamido-oxyacetic acid) [48]... 

Benzadox (and presumably, Irpexll) acts via metabolic conversion within plants to form amlno-oxyacetic acid, which Is a potent pyridoxyl phosphate-requiring enzyme Inhibitor (1901 and also a non-commercial synthetic herbicide (191. 1921. 

Chlorinated phenoxy acids, e.g. 2,4-dichlorophen-oxyacetic acid (2,4-D) and dichlorprop ... 

C9H10O3 benzyl oxyacetic acid 30379-55-6 520.33 45.841 2 16832 C9H11Br 1 -bromo-4-propyl benzene 588-93-2 498.15 43.706 1,2... 

I)iazobenzmie(4-aisinio aoid)-3 -aminoanisic acid 150-155 oxyacetic acid 165... 

Modifications of the oxyacetic acid portions of BRL 37344 (83) has led Lederle researchers to a series of benzodioxole dicarboxylates. CL 316,243 (86) is an extremely potent agonist at the >83 receptor and is devoid of significant activity at the y8, or ySj receptors. Treatment of ob/ob mice with this compound for 1 week normalized plasma glucose levels to that of untreated lean litter-mates and the euglycaemia was maintained for the next 6 weeks of treatment [383]. 

The reaction of alkenes with peroxy acids provides for convenient and selective oxidation of double bonds. The peroxy acids most commonly used in the laboratory are m-chloroperoxybenzoic acid (mCPBA), monoperoxyphthalic acid magnesium salt (MMPP), peroxybenzoic acid, peroxyformic acid, peroxyacetic acid, trifluoroper-oxyacetic acid, and 7-butyl hydroperoxide f(CH3)3COOH]. The order of reactivity for... 

Within (he phennxyacetic acid series (Pig. 18-12). optimal diuretic activity is achieved when (a) an oxyacetic acid mnicty is placed in (he I position on the benzene ring, (h) a sulfhydtyl-reactive acryloyl moiety is located para to the nxyacetic acid group, (c) activating groups (i.c.. Cl- or CH.)-> occupy either the 3 position or the 2 and 3 positions. 

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