Tetracycline, oxy

Discovery of Kanamycin, and Establishment oflMC. Chloramphenicol, chlor- and oxy-tetracyclines, and pyridomycin (H. Umezawa, 1967) were active, in in vitro experiments, against strains of tuberculosis, but these drugs, in contrast to streptomycin, were clinically inactive. H. Umezawa... 

In the area of animal health nutrition a feed-premix containing neomycin and oxy-tetracycline has been described. With neomycin... 

Oxy tetracycline SPFIA (Parallux kit) 300 pg L-1 Bovine and porcine kidney [92]... 

W. N. Barnes, A. Ray, and L. J. Bates, Reversed-phase high-performance liquid chromatographic method for the assay of oxy-tetracycline, J. Chromatogr., 347 173 (1985). 

In chickens orally administered 10 mg/kg of the drug oxy-tetracycline with or without pretreatment with an extract of long pepper (equivalent to 15 mg/kg of piperine) daily for 7 days, an increase in bioavailability and decrease in the elimination rate of oxytetracycline was observed. Long pepper reduced the required loading and maintenance doses by 33.3 and 39%, respectively (Singh et al. 2005). 

D5 41 Protein synthesis Tetracycline antibiotics Oxy-tetracycline Bactericide... 

Gatenbeck, S. The biosynthesis of oxy tetracycline. Biochem. Biophys. Research Commun. 6, 422 (1961). 

Tetracyclines are produced by various Streptomyces strains and are extensively applied in human and veterinary medicine. They display a broad spectrum of antimicrobial activity in combination with low toxicity and can be applied orally. The most commonly prescribed tetracycline drugs are tetracycline itself and oxytetracycline, an oxygenated derivative, which are directly isolated from fermentation liquors, and doxycycline whose partial synthesis from oxy-... 

Dwarf Tetracycline, chior-, oxy-, dimethyl-,and other derivatives root immersion foliar spray girdling mulberry carrot tomato potato rice... 

Fig. 1. Tetracycline (1) and iis derivatives chlorlelracyclinc (7-chlorolclracyclinci (2) oxytetiacycliiic (5-hydrox tetracycline) (3) dcmcclocyclinc (6-dcmethyl-7-chloiolelnicycline) (4) melhacycline (6-deriielliyl-6-deoxy-5-hydi oxy-6-iiielhylenelelnieycline) (5) doxycycline (6u -deoxy-5-hydroxyleU ucycfine) l6> and minocycline (6-demelhyl-6-deoxy-7-dimelhylamino tetracycline) (7). Substituents at posilions not specifically shown or mentioned remain as in (1). Courtesy of Blackwell Scientific Publications, Ltd...

Blanchflower et al. [43] reported the analysis of TC, oxy-TC, and chlor-TC in pig mnscle and kidney tissne by after extraction in a glycine-HCl buffer and solid-phase extraction (SPE) clean np of the extracts. Gradient LC-APCI-MS was performed with 10-90% acetonitrile in water with 0.04% heptafluorobutyric acid, 10 mmol/1 oxalic acid, and 10 gmol/1 EDTA. Detection limits were 10 gg/kg in muscle and 20 gg/kg in kidney. Ion ratio measurements, e.g., on m/z 410, 426, and 445 for tetracycline, were performed for confirmation. 

Trade names Aknin Cotet Macocyn Oxacycle Oxitraklin Oxy Rorap Terramycin (Pfizer) Terramycine Uri-Tet Indications Various infections caused by susceptible organisms Category Antibiotic, tetracycline Half-life 6-10 hours... 

Synthesis of tetracyclines has been assumed to proceed from a malonamyl-CoA starter unit. There are Streptomyces mutants known to produce tetracycline analogs, for example, 2 acetyl-2-decarboxaraide-(oxy)tetracycltne (Table 1), in which the 2-carbox-... 

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