Oxidatively modified molecules

Zeolite Y modified with (+/-)-l,3-dithiane-l-oxide, 1 molecule per super cage... 

Oxidatively modified LDL up-regulates the surfece expression of VCAM-1 and intracellular adhesion molecule-1 (ICAM-1) in cultured endothelial cells, promoting the interactions between both cell types (Kume et al., 1992). This may play a pivotal role in the development of atherosclerosis by promoting the penetration of circulating monocytes into the suben-dothelial space whilst inhibiting the mobility of resident macrophages. It has been previously demonstrated that ICAM-1, E-selectin, and VCAM-1 are up-regulated in the microvasculature of rheumatoid but not control synovium (Corkill et al., 1991 Koch et al., 1991). The association between ox-LDL and increased expression of adhesion molecules in the inflamed synovium has yet to be studied. 

The different degrees of interaction of CO molecules with clean and carbide-modified V(110) surfaces are also reflected in the TDS results. Figure 24.3 shows a comparison of TDS data of molecularly desorbed CO species from clean, carbide-modified and oxide-modified V(110) surfaces. A CO desorption feature is observed at 125 K on all three surfaces, which is due to the desorption of CO molecules from the heating leads. On the clean V(110) surface (Figure 24.3(a)), a relatively weak desorption feature is detected at 208 K. The observation of little molecularly desorbed CO... 

Another approach in generating molecular insulating layers without the need of chemical conversion after deposition is the use of preliminarily modified molecules which can form dense self-assembled monolayers. To create dense self-assembled monolayers with sufficient robustness and insulating properties, a modified alkyltrichlorosilane with an aromatic end-group (18-phenoxyoctadecyl)tri-chlorosilane (PhO-OTS chemical structure Fig. 6.15a) was synthesized and tested [50]. The SAMs were created in a one-step process from vapor phase or solution. On self-assembly on a natively oxidized silicon surface the n-n interaction between the phenoxy end-groups of adjacent molecules creates an intermolecular top-link, leading to a more closely packed surface compared to monolayer than when linear end groups are used. 

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