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Oxidative stress-mediated cell death

More needs to be learned about the role of NO in oxidatively-mediated cell death before it can be used in clinical medicine. The factors that determine under which conditions it is an antioxidant vs prooxidant need to be elucidated since they are likely to include more than just the concentration of NO (Rubbo el al., 1994). For example, the augmenting or mitigating response may also depend upon the nature of the oxidative stress or diseased cell type. [Pg.113]

On the other hand, several ROS are highly cytotoxic. Consequently, eukaryotic cells have developed an elaborate arsenal of antioxidant mechanisms to neutrahze their deleterious effects (enzymes such as superoxide dismutases, catalases, glutathione peroxidases, thioredoxin inhibitors of free-radical chain reaction such as tocopherol, carotenoids, ascorbic acid chelating proteins such as lactoferrin and transferrin). It can be postulated that ROS may induce an oxidative stress leading to cell death when the level of intracellular ROS exceeds an undefined threshold. Indeed, numerous observations have shown that ROS are mediators of cell death, particularly apoptosis (Maziere et al., 2000 Girotti, 1998 Kinscherf et al., 1998 Suzuki et al., 1997 Buttke and Sanstrom, 1994 Albina et al., 1993). [Pg.133]


See other pages where Oxidative stress-mediated cell death is mentioned: [Pg.75]    [Pg.419]    [Pg.299]    [Pg.75]    [Pg.419]    [Pg.299]    [Pg.134]    [Pg.166]    [Pg.134]    [Pg.676]    [Pg.328]    [Pg.70]    [Pg.33]    [Pg.235]    [Pg.142]    [Pg.188]    [Pg.220]    [Pg.411]    [Pg.333]    [Pg.398]    [Pg.248]    [Pg.936]    [Pg.8]    [Pg.44]    [Pg.172]    [Pg.265]    [Pg.14]    [Pg.498]    [Pg.210]    [Pg.15]    [Pg.97]    [Pg.98]    [Pg.240]    [Pg.255]    [Pg.474]    [Pg.264]    [Pg.441]    [Pg.833]    [Pg.801]    [Pg.360]    [Pg.364]    [Pg.75]    [Pg.140]    [Pg.160]    [Pg.164]    [Pg.172]    [Pg.253]    [Pg.834]    [Pg.300]    [Pg.317]   
See also in sourсe #XX -- [ Pg.419 ]




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Cell mediated

Cell stress

Mediated oxidation

Oxidation cell

Oxidation mediators

Oxidative mediators

Oxidative stress

Oxidative stress oxidation

Oxidative/oxidant stress

Oxidized-mediated cell death

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