Oxidative stress and inflammatory signaling

Mitigation of Oxidative Stress and Inflammatory Signaling by Fruit and Walnut Polyphenols Implications for Cognitive Aging... 

The EC-SOD content is very low compared to other SODs in parenchymal cells. However, because it is known that adipose tissue has a moderately high content of EC-SOD, EC-SOD might have an important protective role as an anti-inflammatory factor. In this study, we demonstrated that the expression of EC-SOD was co-regulated with adiponectin through TNF-a and JNK signaling cascades. From these observations, it is speculated that the reduction of EC-SOD by hypoxic conditions is similar to adiponectin and leads to a decrease in the resistance to oxidative stress. Overall, it is speculated that the reduction of EC-SOD leads to decreased resistance to oxidative stress and accelerates ROS-derived diseases, and prevents the reduction of EC-SOD, contributing to the control of redox homeostasis under hypoxic conditions. 

It is now recognised that inflammation plays a pivotal role in early atherogenesis . In particular, monocyte recruitment and adhesion to the nascent atherosclerotic lesion is generally regarded as one of the first steps toward plaque formation. Animal studies have shown that the majority of the cells in the lipid core of atherosclerotic plaques are derived from monocytes. Recent in vitro studies have shown that LR-90 can inhibit inflammatory responses in monocytes treated possibly by its ability to prevent oxidative stress and modulate NF-kB signalling ... 

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