Oxidation, of lipids

Organotin(IV) compounds could be involved in other biological processes occurring in cells, specifically in peroxide oxidation of lipids. The latter process is very important from the viewpoint of physiology, and it follows a radical chain mechanism. ... 

Interaction of lipid oxidation products and amino compounds. Amino acids and primary amines may be involved in other reactions which could lead to the formation of compounds having the potential to undergo N-nitrosation. Malonaldehyde, produced as a result of oxidation of lipids, particularly polyunsaturated fatty acids, has been shown to react with amino acids to produce... 

The oxidation of lipids can be promoted by transition metals, such as copper or haem proteins, by a process that... 

Tsuchija, J. Niki, E. Kamiya, Y. Oxidation of lipids IV. Formation and reaction of chromanoxyl radicals as studied by electron spin resonance. Bull. Chem. Soc. Jpn. 1983, 56, 229-232. 

The reaction of HOC1 with LDL results in apoB modification with little oxidation of lipids by attacking amino groups of apoB lysine residues and the formation of /V-chloramincs, with the latter as the major products of HOC1 reaction with LDL ... 

LOX-catalyzed oxidation of LDL has been studied in subsequent studies [26,27]. Belkner et al. [27] showed that LOX-catalyzed LDL oxidation was not restricted to the oxidation of lipids but also resulted in the cooxidative modification of apoproteins. It is known that LOX-catalyzed LDL oxidation is regio- and enantio-specific as opposed to free radical-mediated lipid peroxidation. In accord with this proposal Yamashita et al. [28] showed that LDL oxidation by 15-LOX from rabbit reticulocytes formed hydroperoxides of phosphatidylcholine and cholesteryl esters regio-, stereo-, and enantio-specifically. Sigari et al. [29] demonstrated that fibroblasts with overexpressed 15-LOX produced bioactive minimally modified LDL, which is probably responsible for LDL atherogenic effect in vivo. Ezaki et al. [30] found that the incubation of LDL with 15-LOX-overexpressed fibroblasts resulted in a sharp increase in the cholesteryl ester hydroperoxide level and a lesser increase in free fatty acid hydroperoxides. 

Kolesova OE, Markin AA, Fedorova TN (1984) Pereoxide oxidation of lipids and the methods for determination of lipid peroxidation produce in the biological mediums. Russian Laboratomoe Delo. 9 540-546. 

The health impairing and toxic elfects of oxidation of lipids are due to loss of vitamins, polyenoic fatty acids, and other nutritionally essential components formation of radicals, hydroperoxides, aldehydes, epoxides, dimers, and polymers and participation of the secondary products in initiation of oxidation of proteins and in the Maillard reaction. Dilferent oxysterols have been shown in vitro and in vivo to have atherogenic, mutagenic, carcinogenic, angiotoxic, and cytotoxic properties, as well as the ability to inhibit cholesterol synthesis (Tai et ah, 1999 Wpsowicz, 2002). 

The oxidation hypothesis of atherosclerosis states that oxidation of lipids in LDL is required for LDL uptake by macrophages and smooth muscle cells in the in-tima of arteries, leading to their transformation to foam... 

Kawagishi, S., T. Oosawa, and H. SI089 Katsuzaki. Pinoresinol glycoside, sesame seed extract containing the glycoside, and its use for preventing oxidation of lipids. Patent-Japan Kokai SI090 Tokkyo Koho-06,116,282 1994 5 pp. 

Many oxygen sensitive products, including food products, electronic components, pharmaceuticals, and medical products, deteriorate in the presence of oxygen. Both the color and the flavor of foods can be adversely affected. The oxidation of lipids within the food product can result in the development of rancidity. These products benefit from the use of oxygen scavengers in their packaging (67). 

A peak is always present at the site of the original spot on the Chromarod when using the Alternate Protocol, especially when analyzing oxidized lipids. This peak can be partly attributed to the oxidation of lipids prior to and during the analysis of lipid classes by TLC-FID. 

Pattison DI, Hawkins CL, Davies MJ (2003) Hypochlorous Acid-Mediated Oxidation of Lipid Components and Antioxidants Present in Low-Density Lipoproteins Absolute Rate Constants, Product Analysis, and Computational Modeling. Chem Res Toxicol 16 439... 

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